Blueprint

Blueprint is a personal endeavor to measure my body’s 70+ organs via hundreds of individual biomarkers, and then reverse the age of each organ by 15 years through targeted interventions.  Hopefully in this journey, there will be clues as to the future of being human.

Last Refreshed: 99 Min ago

Biological Age

36 8

Age Reduction Score

507

Goal is 1,050 points. 15 yrs age reversal for each of my 70 organs.

Organ Systems

Organ / Markers Result Age
PHENOAGE BLOOD PANEL 27.9 years 28
ALBUMIN - N/A
ALP - N/A
CREATININE - N/A
...
GRIMAGE WBC -8 years 36
NAD+ DRIED BLOOD SPOT 35 umol/L 0
Discover all Multi-System Markers
Organ / Markers Age
HEART 45
ARTERIES 50
CAPILLARIES 0
Discover all Cardiovascular Markers
Organ / Markers Age
LYMPH VESSELS & NODES 0
RED BONE MARROW 0
SPLEEN 0
Discover all Immune & RBC Markers
Organ / Markers Age
RETINA 0
LENSES 0
INNER EARS 0
Discover all Eyes & Ears Markers
Organ / Markers Age
CEREBRUM 0
BRAIN STEM 0
VENTRICULAR SYSTEM 0
Discover all Brain & Nerve Markers
Organ / Markers Age
LUNGS 24
TRACHEA 0
LARYNX 0
Discover all Respiratory Markers
Organ / Markers Age
KIDNEYS 33
URETERS 0
BLADDER 0
Discover all Urinary Markers
Organ / Markers Age
SALIVARY GLANDS 0
OESOPHAGUS 0
STOMACH 0
Discover all Oral Gastrointestinal Markers

PMMN = Preliminary, More Measurements Needed

TBM = To Be Measured

Notes

Wins

  • Reduced oral age marker clinical attachment loss (CAL) by 22 years in 120 days1, reversing 20 years of non-diagnosed and improperly treated bruxism. Interestingly, to contrast “norms” with scientific measurement, my (superb) dentist, who helped me with this measurement and intervention protocol, said your gums are normal for a 40-something”. 
    • CAL measurement, whole mouth ave (reference):
      • 3mm, age 84 (3/21)
      • 2.1mm, age 62 (7/21)
  • 7 year age reduction in Horvath-Levine Phenoage Blood Panel, 36.1 to 27.9, between Jan and May 2021, estimated 10 year age reduction after adjusting creatinine down to January levels and taking into account not stopping relatively high dose creatine monohydrate supplements in the 2 weeks prior to the May blood panel.
  • Sleep improvement: night awake time down to < 40 min/ave (WASO), 45% improvement in 90 days (measured w/ Whoop). Hard to pinpoint the exact intervention protocol responsible for the success as am always changing many lifestyle variables. That said, best guess is starting 300mcg of Melatonin before bed had the largest effect.
  • 12 min distance run age marker 18 yrs old (1.63 miles in 12 min, 7:21 pace). Measured w/ Polar H10. (ref: ACSM)
  • 10 day blood glucose is perfect, always between 75-125 mg/dL (using temporary implantable FreeStyle Libre)

In need of some love

  • Forearm and hand skin autofluorescence markers (measured by Diagnoptics MuAGE reader) aged my volar forearm at age 84 (kid sun debauchery). Worth noting, to the naked eye, skin appears healthy and normal. Sun damage is not obvious.
  • UV melanin spots on face and back of hand (using Visia).
  • Free testosterone index (total t/SHBG) currently .29, desired .45. Goal is to find a balance between potential related symptoms and seeing if all or some CRON benefits are related to lowering FTI as assessed by other aging markers.
  • Ferritin levels low at 19 ug/dL, desired 30-60 ug/dL
  • Body fat low at 3.5% (measured daily w/ Withings), desired 5%+
  • MaxHR is currently 174bpm (unsure why), measured w/ Polar H10 (ECG). Desired 190bpm+. Initial research on available interventions to increase MaxHR is not promising. 
  • Intracellular NAD measured 25.9 µM, target 34 µM. Increased NR by 250mg. 

Researching 

  • Interventions to increase maxHR 
  • How to reduce skin autofluorescence 

Changes 

  • Replacing one meal a day and 20+ hour fast with three meals, 10-14 hr fast. Evaluating possible improvement of free testosterone index (Total testosterone/SHBG), increased body fat and improved muscle gain. 

Daily protocol 

Height: 6’0”

Weight: 161 lbs

Body Fat: 3.5%

2,250 calories (17% protein, 35% fat, 47% carbs)

Three meals, 10-14 hr fast 

  • Breakfast: Super Veggie
  • Lunch: leafy greens, vegetables, berries, seeds and nuts 
  • Dinner: Nutty Pudding (sweetened w/Trehalose 7.5g)

Other

  • Olive Oil2, 2 Tbsp (30mL)
  • Spermidine, as chlorella powder, 15g giving 13.5mg spermidine
  • Pea Protein
  • Collagen Peptides
  • Amino complex
  • 2 Tbsp decaf coffee grounds 
  • Cocoa (non-dutched), 10g
  • Creatine, 2g
  • Red wine, 2 oz

Supplements 

w/Breakfast 

  • B Complex (folate/folic acid free, and pre-metabolised forms), 0.15 pill/day
  • BroccoMax 250mg
  • Cocoa Flavanols 900mg
  • D-3 2,000 IU
  • Garlic 2.4g equivalent 
  • Ginger Root 2.2g
  • Glucosamine Sulphate 2KCL 1,500mg
  • Iodine as potassium iodide, 75 micrograms 
  • Lithium, as lithium orotate, 1mg
  • Lycopene 10mg
  • Lysine 1g
  • Nicotinamide Riboside 250mg (7/5 Intracellular NAD measured 25.9 µM, target 34 µM)
  • Turmeric with piperine 1g
  • Taurine 1g
  • Ubiquinol 100mg

w/Lunch 

  • BroccoMax 250mg
  • C (vit) 250
  • Cocoa Flavanols 900mg 
  • D-3 2,000 IU
  • Garlic 2.4g
  • Ginger Root 2.2g
  • Glucosamine Sulphate 2KCL 1,500mg
  • Hyaluronic Acid 300mg
  • Iron 50mg
  • Lithium 1mg
  • Lycopene 10mg
  • Lysine 1g
  • Nicotinamide Riboside 250mg
  • Turmeric 1g
  • Taurine 1g
  • Ubiquinol 100mg

Before bed 

  • DHEA 25 mg 
  • Melatonin 300 mcg

Exercise 

Designed by my 18 yr old son, inspiration by Ben Patrick

60-90 min daily 

HIIT, 45 min weekly

Flows:

Lower A:

A: Sled ROKP, 2 min

B1: Tib Bar/Wall, 4 x 25

B2: Seated Calf/KOT, 4 x 25

C: Poliquin Step-Ups, 5 x 20

D: ATG Split Squats, 10 x 10

E: Rounded Back Extensions, 4 x 25

F: Nordic/Reverse Nordic, 5 x 15

Lower B:

A: Sled ROKP, 2 min

B1: Banded Leg Curls, 3 x 20

B2: Garhammer Raises, 3 x 20

C: VMO Squats, 10 x 10

Stretch Opener: 

A1: Slant Calf Raises, 4 x 10

A2: Slant Jefferson Curls, 4 x 10

A3: L-Sits, 4 x 30 seconds

A4: Cross Bench Pullovers, 4 x 10

A5: External Rotations, 4 x 10

B1: Activation + Side Lying Leg Lifts, 4 x 20

B2: Loaded Butterflies + Standing Groin, 4 x 20

Simple Upper:

A1: Band Pull-Aparts, 5 x 20

A2: Ring Push-Ups, 5 x 10

A3: Ring Rows, 5 x 10

B: Zottman Curls, 4 x 6


1 Intervention protocol to be shared at a later date once stabilized.

2 Highest Quality Extra-Virgin Olive Oil

  • >76% oleic acid 
  • <9 and ideally <6 meq/kg peroxide value
  • <0.3% free fatty acids (FFA)
  • >85% 1.2 DAGs or > 90%
  • >560 mg/kg total phenolics as measured via HPLC total biophenols IOC
  • Less than 8 months old
  • Stored in a cool light free environment