Blueprint is a personal endeavor to measure my body’s 70+ organs via hundreds of individual biomarkers, and then reverse the age of each organ by 15 years through targeted interventions. Hopefully in this journey, there will be clues as to the future of being human.
Last Refreshed: 99 Min ago
Age Reduction Score
Goal is 1,050 points. 15 yrs age reversal for each of my 70 organs.
Reduced oral age marker clinical attachment loss (CAL)by 22 years in 120 days1, reversing 20 years of non-diagnosed and improperly treated bruxism. Interestingly, to contrast “norms” with scientific measurement, my (superb) dentist, who helped me with this measurement and intervention protocol, said “your gums are normal for a 40-something”.
7 year age reduction in Horvath-Levine Phenoage Blood Panel, 36.1 to 27.9, between Jan and May 2021, estimated 10 year age reduction after adjusting creatinine down to January levels and taking into account not stopping relatively high dose creatine monohydrate supplements in the 2 weeks prior to the May blood panel.
Sleep improvement: night awake time down to < 40 min/ave (WASO), 45% improvement in 90 days (measured w/ Whoop). Hard to pinpoint the exact intervention protocol responsible for the success as am always changing many lifestyle variables. That said, best guess is starting 300mcg of Melatonin before bed had the largest effect.
12 min distance run age marker 18 yrs old (1.63 miles in 12 min, 7:21 pace). Measured w/ Polar H10. (ref: ACSM)
10 day blood glucose is perfect, always between 75-125 mg/dL (using temporary implantable FreeStyle Libre)
In need of some love
Forearm and hand skin autofluorescence markers (measured by Diagnoptics MuAGE reader) aged my volar forearm at age 84 (kid sun debauchery). Worth noting, to the naked eye, skin appears healthy and normal. Sun damage is not obvious.
Free testosterone index (total t/SHBG) currently .29, desired .45. Goal is to find a balance between potential related symptoms and seeing if all or some CRON benefits are related to lowering FTI as assessed by other aging markers.
Ferritin levels low at 19 ug/dL, desired 30-60 ug/dL
Body fat low at 3.5% (measured daily w/ Withings), desired 5%+
MaxHR is currently 174bpm (unsure why), measured w/ Polar H10 (ECG). Desired 190bpm+. Initial research on available interventions to increase MaxHR is not promising.
Intracellular NAD measured 25.9 µM, target 34 µM. Increased NR by 250mg.
Interventions to increase maxHR
How to reduce skin autofluorescence
Replacing one meal a day and 20+ hour fast with three meals, 10-14 hr fast. Evaluating possible improvement of free testosterone index (Total testosterone/SHBG), increased body fat and improved muscle gain.